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ucb zilocuplan  (Alexion Phrama)
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Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: <t>zilocuplan;</t> VYV: efgartigimod alfa
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Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: <t>zilocuplan;</t> VYV: efgartigimod alfa
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ucb  (Eli Lilly)
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Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: <t>zilocuplan;</t> VYV: efgartigimod alfa
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ucb  (Boehringer Ingelheim)
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Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: <t>zilocuplan;</t> VYV: efgartigimod alfa
Ucb, supplied by Boehringer Ingelheim, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: zilocuplan; VYV: efgartigimod alfa

Journal: Neurological Sciences

Article Title: Delayed recovery following myasthenic exacerbation and subsequent endplate-protecting treatment

doi: 10.1007/s10072-025-08617-6

Figure Lengend Snippet: Disease course of following myasthenic exacerbation (ME) Time is shown in months; “0” indicates onset of ME. Age and gender of the patient are indicated in the upper left corner of the respective graph. The first five patients received standard-of-care treatment whereas the other seven patients underwent endplate protecting treatment. Abbreviations: SoC: standard-of-care; EPT: endplate protecting treatment; IVIG: intravenous immunoglobulins; PLEX: plasma exchange; QMG: quantitative myasthenia gravis score; MG-ADL: myasthenia gravis activities of daily living questionnaire; AZA: azathioprine, MMF: mycophenolate; MTX: methotrexate; CYC: cyclophosphamide; PYR: pyridostigmin; PRD: prednisolone; RAVU: ravulizumab; ZILO: zilocuplan; VYV: efgartigimod alfa

Article Snippet: Potential conflicts of interest are related to the manufacturers of the endplate-protecting treatments discussed here: UCB (zilocuplan), Argenx (efgartigimod alfa), Alexion (ravulizumab).

Techniques: Clinical Proteomics